Basic Information
VIS ID
TVIS30015398
Fusion event
HIV-SPIRE2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
89934449/89868041 (Hg38)
End
89934560/89868041 (Hg38)
Orient
+
Location type
Intronic
Target gene
SPIRE2
miRNAs that regulate target gene
hsa-mir-6778-3p ; hsa-mir-3137 ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-331-3p ; hsa-mir-6810-3p ; hsa-mir-6801-3p ; hsa-mir-4279 ; hsa-mir-6749-3p ; hsa-mir-4469 ; hsa-mir-5193 ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-498 ; hsa-mir-378a-5p ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-4532 ; hsa-mir-1247-3p
Nearest miRNA
hsa-mir-11401/Upstream/1151704;
Nearest TSS
ENST00000527434/Upstream/4599; ENST00000563032/Downstream/5529;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/13328, chr16-CpG: 151/Downstream/4983
Upstream sequence
GGCAGGAGAAAACTCCTGGAGCCATCCTTCCTGAGAGAATGCCAAGGAGCACATATATTTTGGGTGGATACCTAAGTATAAAGAAAAGCAAGATTTTGGA
Downstream sequence
CCCTGCTGATGCTGCATTTCCTCTGTTCCCTTCCAGAGCCGTCTGCACTTCCTGTAGCATAAAGGTGAGGACCATGTGGGATCTCTGGGGTCTGAGCAAG
Target sequence
GTAAAATAAAGTACTGAAGTAACCAAGCATCAGGCAGAAGGCAAGGATGGTTTGACCTCGGATGCGTGGAGGCCGGGATGCGACTGTTTCTCAGCTGTTTGTGGGCTTCCT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate