Basic Information
VIS ID
TVIS30015399
Fusion event
HIV-PAFAH1B1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
2506886/2603592 (Hg38)
End
2506779/2603592 (Hg38)
Orient
-
Location type
Intronic
Target gene
PAFAH1B1
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-101-3p ; hsa-mir-18a-5p ; hsa-mir-100-5p ; hsa-mir-10a-5p ; hsa-mir-10b-5p ; hsa-mir-339-5p ; hsa-mir-548a-3p ; hsa-mir-616-3p ; hsa-mir-548e-3p ; hsa-mir-548f-3p ; hsa-mir-1250-3p ; hsa-mir-548ar-3p ; hsa-mir-5582-3p ; hsa-mir-548az-3p ; hsa-mir-6732-3p ; hsa-mir-6771-3p ; hsa-mir-105-5p ; hsa-mir-7853-5p ; hsa-mir-32-5p ; hsa-mir-92a-3p ; hsa-mir-92b-3p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-136-5p ; hsa-mir-885-5p ; hsa-mir-607 ; hsa-mir-3156-3p ; hsa-mir-3671 ; hsa-mir-630 ; hsa-mir-4999-5p ; hsa-mir-4718 ; hsa-mir-1537-5p ; hsa-mir-4742-3p ; hsa-mir-532-3p ; hsa-mir-4301 ; hsa-mir-483-3p
Nearest miRNA
hsa-mir-132/Upstream/553212; hsa-mir-10226/Downstream/89269;
Nearest TSS
ENST00000595228/Upstream/9624; ENST00000609078/Downstream/5947;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/8863, chr17-CpG: 68/Downstream/86142
Nearest cancer related gene
PAFAH1B1(TSG, No orient, 0)
Upstream sequence
tgcctgtaatcccagctacttgggaggctgaggcaggagaattgcttgaacccaggaggcagaagttgcagtgagttgagattgcaccactgtactccag
Downstream sequence
cctgggcaaaaagagcaaaacttttgtctcaaggaaaaaaaaaaGTATGTATATATGTATACACACACACATTTTTGTTTTTATTCAATTTCATAAGAAG
Target sequence
tggtagatgcctgtaatcccagctacttgggaggctgaggcaggagaattgcttgaacccaggaggcagaagttgcagtgagttgagattgcaccactgtactccag
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate