Basic Information
VIS ID
TVIS30015402
Fusion event
HIV-UBE2G1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
4192884/4289589 (Hg38)
End
4193009/4289589 (Hg38)
Orient
+
Location type
Intronic
Target gene
UBE2G1
miRNAs that regulate target gene
hsa-mir-18a-5p ; hsa-mir-1226-3p ; hsa-mir-320a ; hsa-mir-4521 ; hsa-mir-6826-5p ; hsa-mir-3158-5p ; hsa-mir-1827 ; hsa-mir-6866-5p ; hsa-mir-155-5p ; hsa-mir-2467-3p ; hsa-mir-6800-5p ; hsa-mir-539-5p ; hsa-mir-1252-5p ; hsa-mir-17-3p ; hsa-mir-1205 ; hsa-mir-1184 ; hsa-mir-3919 ; hsa-mir-6511a-5p ; hsa-mir-1910-3p ; hsa-mir-4759 ; hsa-mir-5197-3p ; hsa-mir-338-5p ; hsa-mir-4517 ; hsa-mir-6507-5p ; hsa-mir-548c-3p ; hsa-mir-493-5p ; hsa-mir-5703 ; hsa-mir-4516 ; hsa-mir-4434 ; hsa-mir-4693-3p ; hsa-mir-6770-5p ; hsa-mir-4712-3p ; hsa-mir-6891-5p ; hsa-mir-3154 ; hsa-mir-3173-3p ; hsa-mir-4428 ; hsa-mir-620 ; hsa-mir-1270 ; hsa-mir-4531 ; hsa-mir-514b-5p ; hsa-mir-513c-5p ; hsa-mir-139-3p ; hsa-mir-4725-5p ; hsa-mir-4670-3p ; hsa-mir-345-3p ; hsa-mir-27b-3p ; hsa-mir-27a-3p
Nearest miRNA
hsa-mir-1253/Upstream/1541407; hsa-mir-10226/Downstream/680113;
Nearest TSS
ENST00000595228/Upstream/21898; ENST00000572078/Downstream/42334;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/25531, chr17-CpG: 178/Downstream/75741
Upstream sequence
TTCACACAGTACCTTTATCAAACATGACACATACGCAGAAGTTAATGTCCAAAATGCAATGTGTTGACTTTTTAAGAAGACTATAGTATAGATTGTACTA
Downstream sequence
AAATGAATAAATAGCAACTATTGGATGTGTTCTTCATTTGCAGAAAGCATATTTTTCCAAAAACTAGCAACTGAGTTTCTATGTAATGGCCTCCTAGTTT
Target sequence
CATACACAGGATCCATCTGACAAACCCAATAGGAATACAAGCTATCTTTTTCATTTATGTAAAACATGAAGATATCTAGCACGTAGATGGTGCCTAACATTTACATGTCTTAAGTATAATATAAT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate