Basic Information
VIS ID
TVIS30015408
Fusion event
HIV-SPAG7 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
4866623/4963328 (Hg38)
End
4866600/4963328 (Hg38)
Orient
-
Location type
Intronic
Target gene
SPAG7
miRNAs that regulate target gene
hsa-mir-615-3p ; hsa-mir-377-3p ; hsa-mir-342-3p ; hsa-mir-4639-3p ; hsa-mir-4643 ; hsa-mir-8485 ; hsa-mir-216b-3p
Nearest miRNA
hsa-mir-1253/Upstream/2215146; hsa-mir-10226/Downstream/6374;
Nearest TSS
ENST00000595228/Upstream/2707; ENST00000576752/Downstream/3421;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/12716, chr17-CpG: 105/Downstream/3566
Upstream sequence
taaaaaataaagaattaggcatgatgatgcatgcctgtagtcccagctactcgggaggctgaggtaggaagatcacttgagcctgagaggtctaggtgac
Downstream sequence
agagcaagaccctgtcaaaaacaaaaacaaaaacaaACCATAATGCATCTGGGAAGGTGAGGAAAACAGACTAAGACCCTGGCCTCAAAGAGTCTGTCAT
Target sequence
tgagcctgagaggtctaggtgac
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate