Basic Information
VIS ID
TVIS30015409
Fusion event
HIV-NLRP1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
5412334/5509014 (Hg38)
End
5412265/5509014 (Hg38)
Orient
-
Location type
Intronic
Target gene
NLRP1
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-1253/Upstream/538864; hsa-mir-10226/Downstream/1146426;
Nearest TSS
ENST00000595228/Upstream/6051; ENST00000563763/Downstream/9551;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/7732, chr17-CpG: 112/Downstream/560981
Upstream sequence
TTATATTAGTTTCTGTGCAACAAGGCCAAAAAAATCTAAGTAATGGACCCAGTGGCCATTTTCAGGATTAACAATACTCTGTGATGGTCTGATTCATGCC
Downstream sequence
CACGCAGACAAAGGTCCTTACCTAACCGCCTAGATGGCCCCGCATTGCCTAGCAACTACCTGCTTAACAGCAGTTGCTAGGAAACCAAGAACACAGCAGG
Target sequence
AAATCTAAGTAATGGACCCAGTGGCCATTTTCAGGATTAACAATACTCTGTGATGGTCTGATTCATGCC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate