Basic Information
VIS ID
TVIS30015415
Fusion event
HIV-POLR2A integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
p13.1
Reference genome
GRCh37/hg19
Start
7396401/7493082 (Hg38)
End
7396350/7493082 (Hg38)
Orient
-
Location type
Intronic
Target gene
POLR2A
miRNAs that regulate target gene
hsa-mir-34a-5p ; hsa-mir-744-5p ; hsa-mir-454-3p ; hsa-mir-652-3p ; hsa-mir-615-3p ; hsa-mir-484 ; hsa-mir-324-5p ; hsa-mir-320a ; hsa-mir-10b-5p ; hsa-mir-10a-5p ; hsa-mir-93-5p ; hsa-mir-17-3p ; hsa-mir-16-5p ; hsa-let-7b-5p ; hsa-mir-1260b ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-1253/Upstream/269703; hsa-mir-10226/Downstream/594974;
Nearest TSS
ENST00000595228/Upstream/8462; ENST00000576952/Downstream/4699;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/8075, chr17-CpG: 50/Downstream/55751
Upstream sequence
TTGAACCTGTCTGAGGCTGAGAGGTGTGCAGAACTTCTTCAGCTTTGCATCTGTAGACCATTTTGGTTTCTACCCAGCAGTGGCCAAtcagacctattat
Downstream sequence
gaggggattactggtttgactgtcagagggtaacctctctttttccaagttttttgagggtacctccctCCAGTGGAGAGTCCTAAGCAGTAGGTCAatt
Target sequence
TCTGTAGACCATTTTGGTTTCTACCCAGCAGTGGCCAAtcagacctattat
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate