Basic Information
VIS ID
TVIS30015418
Fusion event
HIV-NCOR1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
p12
Reference genome
GRCh37/hg19
Start
15992500/16089186 (Hg38)
End
15992672/16089186 (Hg38)
Orient
+
Location type
Intronic
Target gene
NCOR1
miRNAs that regulate target gene
hsa-mir-1301-3p ; hsa-mir-615-3p ; hsa-mir-484 ; hsa-mir-320a ; hsa-let-7b-5p ; hsa-mir-34a-3p
Nearest miRNA
hsa-mir-1253/Upstream/837490; hsa-mir-10226/Downstream/192828;
Nearest TSS
ENST00000595228/Upstream/8673; ENST00000463810/Downstream/2732;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/88812, chr17-CpG: 118/Downstream/125775
Upstream sequence
TATGTTTAAAAAAAAAAATCCACTGGTCATAGTAGTGGTTTTTTTTTTTTTTTAAATGATGGAAATTGGATGGTTCTAAACACAGCTATCTACATCACCA
Downstream sequence
ACTGTAGAAAAGAGGCTTAAAAGTTATCAGTAAAGCAGAGGTCAACTCGTATAAATGTTACTGGTAAGTGAAAACAATTCTCTAAGGTTTTTTTTCAACC
Target sequence
TGTACCCAGAGCAGGAAAAGAAAAACAGCAACAGCAACAAAATAAACATGCAACAAACTAGGGTCAGTTACATAGAAGCATTAACTCTTATTTTAATTGGATAATTTTGTTAAATTTGCATTAGAAGTTCAATTCTAACTCTACCTCCATATGCTTAAGTTTGAGTTCCTTC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate