Basic Information
VIS ID
TVIS30015422
Fusion event
HIV-TOM1L2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
17832995/17929681 (Hg38)
End
17833149/17929681 (Hg38)
Orient
+
Location type
Intronic
Target gene
TOM1L2
miRNAs that regulate target gene
hsa-mir-148b-3p ; hsa-mir-130b-3p ; hsa-mir-26b-5p ; hsa-mir-19b-3p ; hsa-mir-3161 ; hsa-mir-8075 ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-7853-5p ; hsa-mir-105-5p ; hsa-mir-4728-3p ; hsa-mir-513b-3p ; hsa-mir-186-3p ; hsa-mir-5003-5p ; hsa-mir-3714 ; hsa-mir-224-5p ; hsa-mir-548an ; hsa-mir-4446-5p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-4313 ; hsa-mir-670-5p ; hsa-mir-3943
Nearest miRNA
hsa-mir-1253/Upstream/115750; hsa-mir-10226/Downstream/411133;
Nearest TSS
ENST00000595228/Upstream/57617; ENST00000585008/Downstream/42716;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/89007, chr17-CpG: 73/Downstream/42172
Nearest cancer related gene
TOM1L2(TSG, No orient, 0)
Upstream sequence
gatcgcaccattgtactccagcctgggcaacaacagcaaaaactccatctcaaaaacaaaaaaaagaaTGTCAGGAAGAAATCCATAGACTGTCATTTTT
Downstream sequence
CTGCCCTAGAGCTTTAGCTGTGACTGTTGGTATGAACACTTAGACAAGTTAAACACAACATGAATTTCCACAACAGCAAGGCAGCTGCGATGAGTGAGGT
Target sequence
CAGAGCAGTAGTTAACTTTTTGGATAAGATGTTAAAGGAAGAATACATTCCCTTTGAAAATCTGATAAGACCTTTCCAGAGAATTACACACACAATTCTGCACACACTTTCAACAGGTTATTCACCAATCCCTGGCCTCAGTCAGATACCACTT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate