Basic Information
VIS ID
TVIS30015423
Fusion event
HIV-TOP3A integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
18185166/18281852 (Hg38)
End
18185221/18281852 (Hg38)
Orient
+
Location type
Intronic
Target gene
TOP3A
miRNAs that regulate target gene
hsa-mir-320a ; hsa-mir-222-3p ; hsa-mir-6869-5p ; hsa-mir-4279 ; hsa-mir-1200 ; hsa-mir-6829-3p ; hsa-mir-6791-3p ; hsa-mir-3653-5p ; hsa-mir-1976 ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-544b ; hsa-mir-4324 ; hsa-mir-660-3p ; hsa-mir-5571-5p
Nearest miRNA
hsa-mir-1253/Upstream/467921; hsa-mir-10226/Downstream/58962;
Nearest TSS
ENST00000595228/Upstream/6894; ENST00000406438/Downstream/961;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/17566, chr17-CpG: 117/Downstream/32655
Upstream sequence
GGTGAGGAGTTGAGAAACCTCCTTTCTTATTCAGCAGCAAGGAGCACAGCAGTCCCAGGTGGGCCAGGCAGGAtggaaaaaggcagtgaaaacccggttt
Downstream sequence
aagctgcataaaaatccctgccttgcagggtagttaggagaatgggatgaggtaatgcttacagagcaccaccctgcattacaccagtgagggacggcac
Target sequence
caaactctgctgcccaccacggctgcttgactccaagcaagcacctcagccctct
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate