Basic Information
VIS ID
TVIS30015425
Fusion event
HIV-KSR1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
25805204/27478178 (Hg38)
End
25805066/27478178 (Hg38)
Orient
-
Location type
Intronic
Target gene
KSR1
miRNAs that regulate target gene
hsa-mir-378a-3p ; hsa-mir-218-5p ; hsa-mir-4286 ; hsa-mir-140-3p ; hsa-mir-548e-5p
Nearest miRNA
hsa-mir-1180/Upstream/184182; hsa-mir-10226/Downstream/882476;
Nearest TSS
ENST00000595228/Upstream/6165; ENST00000398985/Downstream/82139;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/20846, chr17-CpG: 20/Downstream/127293
Upstream sequence
tttaaggacagactatgtcatgacctttttacccagaaattccagggcttagcccagtacttggcacacagtaagtgctgaggaattgAACGAGGGTTCT
Downstream sequence
GGAGTATGTGCTTTAATCAGGGCTAAACTAACCTCACAGCATTCCTAGGAAAATAACACAAACCGGTATAAAAGGGGATGGTGTCAGggttaggagtgtg
Target sequence
TAAAGCCCTCTAGCTTCAAAGGAAGGAGTTCTTCTTtctttaaggacagactatgtcatgacctttttacccagaaattccagggcttagcccagtacttggcacacagtaagtgctgaggaattgAACGAGGGTTCT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate