Basic Information
VIS ID
TVIS30015440
Fusion event
HIV-SSH2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
28166950/29839932 (Hg38)
End
28166827/29839932 (Hg38)
Orient
-
Location type
Intronic
Target gene
SSH2
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-130b-5p ; hsa-mir-222-3p ; hsa-mir-20a-5p ; hsa-mir-155-5p ; hsa-mir-106b-5p ; hsa-mir-526b-5p ; hsa-mir-4445-5p ; hsa-mir-6766-3p ; hsa-mir-4782-3p ; hsa-mir-219a-5p ; hsa-mir-508-3p ; hsa-mir-574-5p ; hsa-mir-4693-3p ; hsa-mir-5584-3p ; hsa-mir-4311 ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-196a-3p ; hsa-mir-6860 ; hsa-mir-661 ; hsa-mir-612 ; hsa-mir-5189-5p ; hsa-mir-3187-5p ; hsa-mir-1285-3p ; hsa-mir-766-3p ; hsa-mir-939-3p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-6849-3p ; hsa-mir-759 ; hsa-mir-5586-3p ; hsa-mir-508-5p ; hsa-mir-4797-5p ; hsa-mir-623 ; hsa-mir-6780b-3p ; hsa-mir-4780 ; hsa-mir-26a-5p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-93-5p ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-1180/Upstream/449202; hsa-mir-10226/Downstream/277147;
Nearest TSS
ENST00000595228/Upstream/790; ENST00000584258/Downstream/23470;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/78343, chr17-CpG: 60/Downstream/89876
Upstream sequence
aagagcaccggctgggagtgtcaggcagacttagctgtcactaccagcatggtcacataccttaagcaagcctggttcctcacctttaaacagggactac
Downstream sequence
taaaagtatttgcctcaaagacttggattcaacactaaactgtataaaaagcatttagtacaatgggtgtcacatggtaagtactcaTAGTAAGGGGTCC
Target sequence
CAAAGGCAATCCAGCATAAGTTaaagagcaccggctgggagtgtcaggcagacttagctgtcactaccagcatggtcacataccttaagcaagcctggttcctcacctttaaacagggactac
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate