Basic Information
VIS ID
TVIS30015441
Fusion event
HIV-NSRP1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
28506782/30179764 (Hg38)
End
28506635/30179764 (Hg38)
Orient
-
Location type
Intronic
Target gene
NSRP1
miRNAs that regulate target gene
hsa-mir-324-3p ; hsa-mir-186-5p
Nearest miRNA
hsa-mir-1180/Upstream/62592; hsa-mir-10226/Downstream/914586;
Nearest TSS
ENST00000595228/Upstream/34974; ENST00000581633/Downstream/23918;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/62771, chr17-CpG: 74/Downstream/55605
Upstream sequence
GGATGAGAAAATAATAGAGTAACACCACTCAAGGAGGATCAATGAGGCAATTAGAAAAAGAATAACATTAATTGAAGAAAGAATAAAAATTGGATGAATT
Downstream sequence
AAGAATATCTTAATGCTTTACCTTAGTGCTTTCTACTCATGATTATTTCTCAAGATCTAAGTAGAATATGTATTTATAAAATACttttttttttgagact
Target sequence
TCAGAAACAATATAAATATAATTTTAAACCCTAGTTACATTTTTTTGGGATGAGAAAATAATAGAGTAACACCACTCAAGGAGGATCAATGAGGCAATTAGAAAAAGAATAACATTAATTGAAGAAAGAATAAAAATTGGATGAATT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate