Basic Information
VIS ID
TVIS30015447
Fusion event
HIV-CPD integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
28748473/30421455 (Hg38)
End
28748264/30421455 (Hg38)
Orient
-
Location type
Intronic
Target gene
CPD
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-196a-5p ; hsa-mir-19b-3p ; hsa-mir-320a ; hsa-mir-432-5p ; hsa-mir-214-3p
Nearest miRNA
hsa-mir-1180/Upstream/304283; hsa-mir-10226/Downstream/672895;
Nearest TSS
ENST00000595228/Upstream/41219; ENST00000581826/Downstream/17530;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/41655, chr17-CpG: 28/Downstream/55863
Upstream sequence
TCACCCAGACTAATACAGCAATTGAATACACCAGCAGTTACACCTTGTTGAGAAAATTAGAAATCTGGCTTTGAGGAGAGGGAATTTTAAAAGCACCTTA
Downstream sequence
CTAGTGTCGAGTTCAGACATATGACTTAAGTTTAAGGATTTAATACTTCTGTCTGTATTTTATTTAAACTTCAAGGGATTGAAAATGTTTTGGGGGAGAG
Target sequence
AAATAATTAGCCAAATTTGTACTCTCAGGTTCTTACAATGTCATGTGATCATATTTGCTAGTGAGCCTTTACCACTATATGAACCATAGACATCAGTTTAATTTAAACATCACCCAGACTAATACAGCAATTGAATACACCAGCAGTTACACCTTGTTGAGAAAATTAGAAATCTGGCTTTGAGGAGAGGGAATTTTAAAAGCACCTTA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate