Basic Information
VIS ID
TVIS30015451
Fusion event
HIV-SLFN5 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q12
Reference genome
GRCh37/hg19
Start
33573066/35246047 (Hg38)
End
33573188/35246047 (Hg38)
Orient
+
Location type
Intronic
Target gene
SLFN5
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-3613-3p ; hsa-mir-127-5p ; hsa-mir-7843-3p ; hsa-mir-4635 ; hsa-mir-100-3p ; hsa-mir-4783-5p ; hsa-mir-6767-3p ; hsa-mir-8485 ; hsa-mir-627-5p ; hsa-mir-924 ; hsa-mir-4682 ; hsa-mir-4653-5p ; hsa-mir-3921 ; hsa-mir-301b-5p ; hsa-mir-301a-5p ; hsa-mir-146a-3p ; hsa-mir-30e-5p ; hsa-mir-30d-5p ; hsa-mir-30c-5p ; hsa-mir-30b-5p ; hsa-mir-30a-5p ; hsa-mir-4286 ; hsa-mir-6777-3p ; hsa-mir-4639-3p ; hsa-mir-6771-3p ; hsa-mir-1178-3p ; hsa-mir-6864-3p ; hsa-mir-3672 ; hsa-mir-6847-3p ; hsa-mir-769-5p ; hsa-mir-4786-5p ; hsa-mir-3121-5p ; hsa-mir-153-5p ; hsa-mir-1250-3p
Nearest miRNA
hsa-mir-1180/Upstream/2895845; hsa-mir-10226/Downstream/1787698;
Nearest TSS
ENST00000595228/Upstream/2958; ENST00000591886/Downstream/67455;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/2539, chr17-CpG: 23/Downstream/127421
Upstream sequence
tatatccctacaaggagtatatgacgatgcccattccttcacatcttcaccaacaactagcatggttagtcattttagccattctaatagatgtgtagtg
Downstream sequence
tttttaaattgggtttttttatcattactttttgagtgttctatatataatctacttacaagttctttatcagttatgtaatttgcaaataccttcttcc
Target sequence
gtatctcactgaagttttaataggcatttccctaacgactaatgatgttgagcataattcaatgtgcttatttgtatccatatattttctttggtaaattgtctattcaagtattttattca
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate