Basic Information
VIS ID
TVIS30015452
Fusion event
HIV-SLFN12 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q12
Reference genome
GRCh37/hg19
Start
33744810/35417791 (Hg38)
End
33744741/35417791 (Hg38)
Orient
-
Location type
Intronic
Target gene
SLFN12
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-4446-5p ; hsa-mir-1238-3p ; hsa-mir-670-3p ; hsa-mir-616-3p ; hsa-mir-3124-3p ; hsa-mir-6072 ; hsa-mir-6891-3p ; hsa-mir-153-5p ; hsa-mir-6785-3p ; hsa-mir-6803-5p ; hsa-mir-7109-5p ; hsa-mir-4472 ; hsa-mir-4447 ; hsa-mir-92a-2-5p ; hsa-mir-6766-5p ; hsa-mir-6756-5p ; hsa-mir-608 ; hsa-mir-4651 ; hsa-mir-6885-5p ; hsa-mir-328-5p ; hsa-mir-6887-5p ; hsa-mir-6795-5p ; hsa-mir-7111-5p ; hsa-mir-6870-5p ; hsa-mir-5698 ; hsa-mir-4723-5p ; hsa-mir-6782-5p
Nearest miRNA
hsa-mir-1180/Upstream/3067589; hsa-mir-10226/Downstream/1615954;
Nearest TSS
ENST00000595228/Upstream/13418; ENST00000587076/Downstream/2974;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/9951, chr17-CpG: 18/Downstream/30759
Upstream sequence
attttatgatctgcatatttgtttatacaaaatgtaaataatctatggacagattatttaaaataataaggaaacctaacaatgtggccttatataaact
Downstream sequence
cagtatgtaaaaatcaactgcatttctacacattagcaataaacaagaaaatggaacttttaaaaaaaatatctttacaacaacaaaaataaaaggaacc
Target sequence
atgtaaataatctatggacagattatttaaaataataaggaaacctaacaatgtggccttatataaact
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate