Basic Information
VIS ID
TVIS30015454
Fusion event
HIV-AP2B1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q12
Reference genome
GRCh37/hg19
Start
33947964/35620945 (Hg38)
End
33947990/35620945 (Hg38)
Orient
+
Location type
Intronic
Target gene
AP2B1
miRNAs that regulate target gene
hsa-mir-34a-5p ; hsa-mir-16-5p ; hsa-mir-877-3p ; hsa-mir-744-5p ; hsa-mir-532-3p ; hsa-mir-615-3p ; hsa-mir-106b-5p ; hsa-mir-99a-5p ; hsa-mir-92a-3p ; hsa-mir-19b-3p ; hsa-mir-188-5p ; hsa-mir-623 ; hsa-mir-4780 ; hsa-mir-6866-3p ; hsa-mir-4325 ; hsa-mir-7703 ; hsa-mir-656-5p ; hsa-mir-6780b-3p ; hsa-mir-15a-5p ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-214-3p ; hsa-mir-31-5p ; hsa-mir-3619-5p ; hsa-mir-3665 ; hsa-mir-3688-5p ; hsa-mir-424-5p ; hsa-mir-4524a-5p ; hsa-mir-4524b-5p ; hsa-mir-497-5p ; hsa-mir-503-5p ; hsa-mir-646 ; hsa-mir-6809-5p ; hsa-mir-6815-5p ; hsa-mir-6838-5p ; hsa-mir-6865-5p ; hsa-mir-761
Nearest miRNA
hsa-mir-1180/Upstream/3270743; hsa-mir-10226/Downstream/1412800;
Nearest TSS
ENST00000595228/Upstream/13108; ENST00000588116/Downstream/330;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/23820, chr17-CpG: 74/Downstream/110585
Upstream sequence
AACTCTAATTTTTCTGAAATGGTAGCTAAAGGCCATTGTTCTCTTTCTGTCAGTATTTCCTAAGAGAAATGCCAATTTTTTGACAGGAGAAGTGTTACAC
Downstream sequence
AAGTAATAGTTCAAATGAAAGAAGCACACCTTTGTCTTAGTATACAGGTGAGTCAAGGCAGTTATTGTAAGGGTTGGATTTGTTCTTTTGTGATATTATT
Target sequence
ATAGTTGTGTTAACAGTTCTAAATCA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate