Basic Information
VIS ID
TVIS30015460
Fusion event
HIV-CDK12 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q12
Reference genome
GRCh37/hg19
Start
37685987/39529734 (Hg38)
End
37685876/39529734 (Hg38)
Orient
-
Location type
Intronic
Target gene
CDK12
miRNAs that regulate target gene
hsa-mir-744-5p ; hsa-mir-503-5p ; hsa-mir-193b-3p ; hsa-mir-193a-3p ; hsa-mir-10b-5p ; hsa-mir-4443 ; hsa-mir-6515-5p ; hsa-mir-9-5p ; hsa-mir-130b-5p ; hsa-mir-4762-5p ; hsa-mir-216b-5p ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa ; hsa-mir-4753-3p ; hsa-mir-6894-5p ; hsa-mir-765 ; hsa-mir-7154-3p ; hsa-mir-766-5p ; hsa-mir-3613-3p ; hsa-mir-3617-3p ; hsa-mir-4311 ; hsa-mir-4524a-3p ; hsa-mir-545-3p ; hsa-mir-548p
Nearest miRNA
hsa-mir-1180/Upstream/232225; hsa-mir-10226/Downstream/196761;
Nearest TSS
ENST00000595228/Upstream/3867; ENST00000584336/Downstream/148;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/67942, chr17-CpG: 51/Downstream/43724
Upstream sequence
CCTTGGCAGGAGTTCATTATCAGACAATGTTTATCATGCTTAAGCACATTTAGGCAGCAGTGGAAAAAAGAAAGTCTGGTGGAAGTAGTTCAAGAAAGAC
Downstream sequence
AAAAGATCTTTGTAAAGACAGAGTATAGTATGAATTTAATATATTTCTAAATATTTAGTTCTTGTCACCGTCTCCAAGATAAACAGATGTTTATCAACAG
Target sequence
CTCCTCTCCTGCCTTGGCAGGAGTTCATTATCAGACAATGTTTATCATGCTTAAGCACATTTAGGCAGCAGTGGAAAAAAGAAAGTCTGGTGGAAGTAGTTCAAGAAAGAC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate