Basic Information
VIS ID
TVIS30015466
Fusion event
HIV-TOP2A integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
38561073/40404821 (Hg38)
End
38561171/40404821 (Hg38)
Orient
+
Location type
Exonic
Target gene
TOP2A
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-21-5p ; hsa-mir-1226-3p ; hsa-mir-708-5p ; hsa-mir-186-5p ; hsa-mir-7-5p ; hsa-mir-218-5p ; hsa-mir-203a-3p ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-3668 ; hsa-mir-4524b-3p ; hsa-mir-7-2-3p ; hsa-mir-7-1-3p ; hsa-mir-5688 ; hsa-mir-495-3p ; hsa-mir-561-3p
Nearest miRNA
hsa-mir-1180/Upstream/211158; hsa-mir-10226/Downstream/1112343;
Nearest TSS
ENST00000595228/Upstream/5560; ENST00000269593/Downstream/12884;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/40809, chr17-CpG: 47/Downstream/12643
Upstream sequence
TTGCTATAGTATCAATACCAAAAGGTCAGTCTAACAATCCATTTTGTGGCATATATTTAAAACTTTTACCTCAGGAAGCCCAAGTAACTTTCGTTGTCTT
Downstream sequence
AATAGGCTAATAGGTTCCAAAATATCCTTCTACAAAGAACGAACAACAGAAAAACAAAAATACTGttttcctttttttttttttttgagacgggagttac
Target sequence
CTATCCTCCATGAAATTAGTTAACCATTCCTTTCGATCATCTATCTGTTTTTTGCTAAAGGCCTATAAATTAAAGGATGAAAAGATGTCACTGGTACT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate