Basic Information
VIS ID
TVIS30015477
Fusion event
HIV-KLHL11 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q21.2
Reference genome
End
40006450/41850386 (Hg38)
Orient
-
Location type
Intronic
Target gene
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-615-3p ; hsa-mir-92a-3p ; hsa-let-7b-5p ; hsa-mir-132-3p ; hsa-mir-6858-5p ; hsa-mir-4689 ; hsa-mir-3915 ; hsa-mir-1224-5p ; hsa-mir-6864-3p ; hsa-mir-3672 ; hsa-mir-3928-3p ; hsa-mir-769-5p ; hsa-mir-4786-5p ; hsa-mir-708-5p ; hsa-mir-3139 ; hsa-mir-28-5p ; hsa-mir-3907 ; hsa-mir-4720-3p ; hsa-mir-4804-3p ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-3973 ; hsa-mir-3163 ; hsa-mir-559 ; hsa-mir-548y ; hsa-mir-548w ; hsa-mir-548o-5p ; hsa-mir-548j-5p ; hsa-mir-548i ; hsa-mir-548h-5p ; hsa-mir-548d-5p ; hsa-mir-548c-5p ; hsa-mir-548bb-5p ; hsa-mir-548b-5p ; hsa-mir-548ay-5p ; hsa-mir-548au-5p ; hsa-mir-548as-5p ; hsa-mir-548ar-5p ; hsa-mir-548aq-5p ; hsa-mir-548ap-5p ; hsa-mir-548am-5p ; hsa-mir-548ak ; hsa-mir-548ad-5p ; hsa-mir-548ae-5p ; hsa-mir-548ab ; hsa-mir-548a-5p ; hsa-mir-4282 ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-127-5p ; hsa-mir-7843-3p ; hsa-mir-1468-3p ; hsa-mir-4635 ; hsa-mir-4698 ; hsa-mir-548p ; hsa-mir-3662 ; hsa-mir-9-3p ; hsa-mir-4422 ; hsa-mir-6835-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-6829-3p ; hsa-mir-6791-3p ; hsa-mir-18a-3p ; hsa-mir-324-3p ; hsa-mir-1913 ; hsa-mir-519d-5p ; hsa-mir-5193 ; hsa-mir-1224-3p ; hsa-mir-1273g-3p ; hsa-mir-1285-3p ; hsa-mir-196a-3p ; hsa-mir-3187-5p ; hsa-mir-3613-3p ; hsa-mir-4793-3p ; hsa-mir-500a-3p ; hsa-mir-508-5p ; hsa-mir-5189-5p ; hsa-mir-612 ; hsa-mir-6512-3p ; hsa-mir-661 ; hsa-mir-6720-5p ; hsa-mir-6849-3p ; hsa-mir-6860 ; hsa-mir-766-3p ; hsa-mir-767-5p ; hsa-mir-7703 ; hsa-mir-939-3p
Nearest miRNA
hsa-mir-1180/Upstream/333169; hsa-mir-10226/Downstream/644387;
Nearby gene
KLHL10(No orient, 2039)
Upstream sequence
CCTGCACACATCATCATGCAATGAAGGACTTACCCCTTCTTTTCAGCCATGGCCTAGGCTGCCTGCTAAGTTAAAAAACAACAGTTTCAATCAAGGTTTT
Downstream sequence
AAAACCAGATTATGCCTAAATCTTATGAGTTATAATTTCTGTCACATGATGTGAAAAAAACACAACCCCACAAATGACTTGGTAATAATTATCTCAGAAG
Target sequence
AAGTTAGTTAGGATATTTCAGAAACACAAGTTATTGATGTGAAATTACACATGTGAATTCAAAAATAAAAATTAGAAAATCAGGAAAACCTGCACACATCATCATGCAATGAAGGACTTACCCCTTCTTTTCAGCCATGGCCTAGGCTGCCTGCTAAGTTAAAAAACAACAGTTTCAATCAAGGTTTT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate