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TVIS30015477
Basic Information
VIS ID
TVIS30015477
Fusion event
HIV-KLHL11 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
40006638/41850386 (Hg38)
End
40006450/41850386 (Hg38)
Orient
-
Location type
Intronic
Target gene
KLHL11
miRNAs that regulate target gene
hsa-mir-335-5p
;
hsa-mir-615-3p
;
hsa-mir-92a-3p
;
hsa-let-7b-5p
;
hsa-mir-132-3p
;
hsa-mir-6858-5p
;
hsa-mir-4689
;
hsa-mir-3915
;
hsa-mir-1224-5p
;
hsa-mir-6864-3p
;
hsa-mir-3672
;
hsa-mir-3928-3p
;
hsa-mir-769-5p
;
hsa-mir-4786-5p
;
hsa-mir-708-5p
;
hsa-mir-3139
;
hsa-mir-28-5p
;
hsa-mir-3907
;
hsa-mir-4720-3p
;
hsa-mir-4804-3p
;
hsa-mir-520h
;
hsa-mir-520g-3p
;
hsa-mir-3973
;
hsa-mir-3163
;
hsa-mir-559
;
hsa-mir-548y
;
hsa-mir-548w
;
hsa-mir-548o-5p
;
hsa-mir-548j-5p
;
hsa-mir-548i
;
hsa-mir-548h-5p
;
hsa-mir-548d-5p
;
hsa-mir-548c-5p
;
hsa-mir-548bb-5p
;
hsa-mir-548b-5p
;
hsa-mir-548ay-5p
;
hsa-mir-548au-5p
;
hsa-mir-548as-5p
;
hsa-mir-548ar-5p
;
hsa-mir-548aq-5p
;
hsa-mir-548ap-5p
;
hsa-mir-548am-5p
;
hsa-mir-548ak
;
hsa-mir-548ad-5p
;
hsa-mir-548ae-5p
;
hsa-mir-548ab
;
hsa-mir-548a-5p
;
hsa-mir-4282
;
hsa-mir-19a-3p
;
hsa-mir-19b-3p
;
hsa-mir-127-5p
;
hsa-mir-7843-3p
;
hsa-mir-1468-3p
;
hsa-mir-4635
;
hsa-mir-4698
;
hsa-mir-548p
;
hsa-mir-3662
;
hsa-mir-9-3p
;
hsa-mir-4422
;
hsa-mir-6835-3p
;
hsa-mir-6792-3p
;
hsa-mir-4691-5p
;
hsa-mir-6829-3p
;
hsa-mir-6791-3p
;
hsa-mir-18a-3p
;
hsa-mir-324-3p
;
hsa-mir-1913
;
hsa-mir-519d-5p
;
hsa-mir-5193
;
hsa-mir-1224-3p
;
hsa-mir-1273g-3p
;
hsa-mir-1285-3p
;
hsa-mir-196a-3p
;
hsa-mir-3187-5p
;
hsa-mir-3613-3p
;
hsa-mir-4793-3p
;
hsa-mir-500a-3p
;
hsa-mir-508-5p
;
hsa-mir-5189-5p
;
hsa-mir-612
;
hsa-mir-6512-3p
;
hsa-mir-661
;
hsa-mir-6720-5p
;
hsa-mir-6849-3p
;
hsa-mir-6860
;
hsa-mir-766-3p
;
hsa-mir-767-5p
;
hsa-mir-7703
;
hsa-mir-939-3p
Nearest miRNA
hsa-mir-1180/Upstream/333169; hsa-mir-10226/Downstream/644387;
Nearest TSS
ENST00000595228/Upstream/12561;
ENST00000619176/Downstream/15045;
Nearest CpG islands
None/Target,
chr17-CpG: 26/Upstream/14011
,
chr17-CpG: 85/Downstream/14432
Nearby gene
KLHL10
(No orient, 2039)
Upstream sequence
CCTGCACACATCATCATGCAATGAAGGACTTACCCCTTCTTTTCAGCCATGGCCTAGGCTGCCTGCTAAGTTAAAAAACAACAGTTTCAATCAAGGTTTT
Downstream sequence
AAAACCAGATTATGCCTAAATCTTATGAGTTATAATTTCTGTCACATGATGTGAAAAAAACACAACCCCACAAATGACTTGGTAATAATTATCTCAGAAG
Target sequence
AAGTTAGTTAGGATATTTCAGAAACACAAGTTATTGATGTGAAATTACACATGTGAATTCAAAAATAAAAATTAGAAAATCAGGAAAACCTGCACACATCATCATGCAATGAAGGACTTACCCCTTCTTTTCAGCCATGGCCTAGGCTGCCTGCTAAGTTAAAAAACAACAGTTTCAATCAAGGTTTT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Sample Information
×
Sample name
PT4
Sample type
PBMC
Age
39
Gender
Male
CpG Island Information
×
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