Basic Information
VIS ID
TVIS30015479
Fusion event
HIV-DNAJC7 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
40152722/42000704 (Hg38)
End
40152912/42000704 (Hg38)
Orient
+
Location type
Intronic
Target gene
DNAJC7
miRNAs that regulate target gene
hsa-mir-181a-5p ; hsa-mir-877-3p
Nearest miRNA
hsa-mir-1180/Upstream/483487; hsa-mir-10226/Downstream/494069;
Nearest TSS
ENST00000595228/Upstream/7922; ENST00000587028/Downstream/10571;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/32251, chr17-CpG: 67/Downstream/16277
Upstream sequence
TACAAAGGGAATAACCTCTGTAATCTTACAGGAGGAATCTTTGGTCTAGAGCCCGCAGCACACTGAGCTGAAAGTTAGTGTGATACTTGAAGGATTTATA
Downstream sequence
GCAAGGAATTTTTCTATCTCCTTCCACAGTGTCACAACTGCTGCCTCTTTTGCAAACTTACAGGAAAAATGGTTACTCCATTCAGGGCAACTTATTTCTC
Target sequence
GATTTGTTGAATAGGCCAATGGACCAAAAGGAGGTGCTAATGAAAGAATCCAAGTTCTTCAGATGCTCCTTTTTGTCACTTAGATACATTCAAACTAAATCAAGAAAACCCCTCTTATGTTCCTGCCTCACCTCACTATTTCTGCCTGTAGTCATCCTCCCCGCAGGACAAATTTAGACATTCCCTCATG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate