VISDB Viral Integration Site DataBase

VIS ID

TVIS30015505

Fusion event

HIV-BRCA1 integration

Validated

Yes

Detection method

LM PCR

Data source

Curated

Sample type

Disease

HIV-infected disease (HID)

Quality evaluation

Good

Reported year

2014

PubMed ID

Virus name

HIV

Reference genome

Not given

Chromosome

chr17

Cytoband

q21.31

Reference genome

Start

End

41237361/43085555 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-146a-5p ; hsa-mir-16-5p ; hsa-mir-15a-5p ; hsa-mir-212-3p ; hsa-mir-24-3p ; hsa-mir-193b-3p ; hsa-mir-335-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-21-5p ; hsa-mir-99b-3p ; hsa-mir-484 ; hsa-mir-186-5p ; hsa-mir-181a-5p ; hsa-mir-20b-5p ; hsa-mir-498 ; hsa-mir-4465 ; hsa-mir-26b-5p ; hsa-mir-26a-5p ; hsa-mir-4726-3p ; hsa-mir-1297 ; hsa-mir-6872-3p ; hsa-mir-125a-3p ; hsa-mir-34a-5p ; hsa-mir-483-3p ; hsa-mir-10b-5p

Nearest miRNA

hsa-mir-1180/Upstream/261612; hsa-mir-10226/Downstream/359251;

Nearest TSS

Nearest CpG islands

None/Target, chr17-CpG: 26/Upstream/59979, chr17-CpG: 24/Downstream/40562

Nearest cancer related gene

BRCA1(TSG, No orient, 0)

Upstream sequence

GATAAAATTCCTCAACATAGCATTCAAAAGGCCCTTTATACCCTGGTATTATCTCTCATTTCTCCCAACACCCCTCACACAAGTTGTTTTCCTATAACAC

Downstream sequence

ATGACAACTTTACGTTTCCTGGGAATTCCATGACTCTGTACCTTTACCTTACTTGCTGCCACTCCTCTTTTTCCACTTGGAAAAATTCTCATCTTTCAAG

Target sequence

gcaaaactctgtctcaaaaaaaaaaagaaaagaaaaaaaCCCTTAGTGGTATACCACTGCTGATTTATACTTTTTGAACACTATATAATTGTTAGTCATTACTGCCATTAGGATAAAATTCCTCAACATAGCATTCAAAAGGCCCTTTATACCCTGGTATTATCTCTCATTTCTCCCAACACCCCTCACACAAGTTGTTTTCCTATAACAC