Basic Information
VIS ID
TVIS30015510
Fusion event
HIV-ARHGAP27 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q21.31
Reference genome
GRCh37/hg19
Start
43482547/45405181 (Hg38)
End
43482603/45405181 (Hg38)
Orient
+
Location type
Intronic
Target gene
ARHGAP27
miRNAs that regulate target gene
hsa-mir-198 ; hsa-mir-4726-3p ; hsa-mir-1324 ; hsa-mir-589-3p ; hsa-mir-500b-3p ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-1199-3p ; hsa-mir-4632-3p ; hsa-mir-1908-3p
Nearest miRNA
hsa-mir-1180/Upstream/290748; hsa-mir-10226/Downstream/70182;
Nearest TSS
ENST00000595228/Upstream/479; ENST00000433601/Downstream/753;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/8204, chr17-CpG: 29/Downstream/581
Upstream sequence
GGTAGTCCGTCTCGGGAGTGGGGGGCTGCGGGGAACAGAAGGTGGAGTCAGAGGCTCTGAGTGCCAGTACTGCCTGCTGGCCCTGCCGTTTTGGACCAGG
Downstream sequence
GCGCTCAGAGGTAGCTCCGCACCTCACCCTCTGGTCCCTGGGGCTGTGGGAGCAGAAGGCGTCAGAGGTAGCCCCGCCCACTCCAGCCCTGCCCCTCACC
Target sequence
CCCACCCCCTTGCCTTCTGGTCCCTGAGGCTGTGGGAGCAGGAGGCGGGGTCAGAA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate