Basic Information
VIS ID
TVIS30015517
Fusion event
HIV-chr17 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q21.33
Reference genome
GRCh37/hg19
Start
47481232/49403870 (Hg38)
End
47481406/49403870 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10226/Upstream/115416; hsa-mir-1250/Downstream/106947;
Nearest TSS
ENST00000595228/Upstream/28490; ENST00000506504/Downstream/211;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/41294, chr17-CpG: 42/Downstream/66139
Nearby gene
PHB(No orient, 187)
Nearest cancer related gene
PHB(TSG, No orient, 187)
Upstream sequence
CTCCCAGTGAGTAGTGGCACCAAAACACACAGAACAAGTTAACTGCCCTCCACCTACCTTCACTGCCTATCCCATGACAAACCTCACCTGCTACCACAGA
Downstream sequence
CCATGGCTGAGCCGGAAGGTCTGGGTGTCATTTATTGACAGCAGTTTATACACATTTGTTTCCTTCCCAGTGCAGGCATAGAGCCCGTGAGAAGGGCAGT
Target sequence
GATTCCCTTCGGGTTGGGGATGGATCTGGAACACAACACAAAGTGTTTTCTGAAAACAAAGCATTTTCTGCCTTACTGGAGACTCTGTCCCAGCTGGCAATGCAAACATGTACACACAAAAACTGCTAGAACACTCTGTTCTGATCCCACGGCTCCCACAAACAAAAAACCAAC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate