VISDB - VIS Detail

Basic Information

VIS ID

TVIS30015518

Fusion event

HIV-SPOP integration

Validated

Yes

Detection method

LM PCR

Data source

Curated

Sample type

PBMC

Disease

HIV-infected disease (HID)

Quality evaluation

Good

Reported year

2014

PubMed ID

24968937

Virus Sequence

Virus name

HIV

Reference genome

Not given

Host Sequence

Chromosome

chr17

Cytoband

q21.33

Reference genome

GRCh37/hg19

Start

47709840/49632478 (Hg38)

End

47709810/49632478 (Hg38)

Orient

Location type

Intronic

Target gene

SPOP

miRNAs that regulate target gene

hsa-mir-4503 ; hsa-mir-3117-3p ; hsa-mir-6792-5p ; hsa-mir-8063 ; hsa-mir-4698 ; hsa-mir-6866-3p ; hsa-mir-188-5p ; hsa-mir-8083 ; hsa-mir-3169 ; hsa-mir-4759 ; hsa-mir-605-5p ; hsa-mir-4668-3p ; hsa-mir-6739-3p ; hsa-mir-375 ; hsa-mir-599 ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-7156-5p ; hsa-mir-4677-5p ; hsa-mir-4273 ; hsa-mir-3161 ; hsa-mir-6873-3p ; hsa-mir-6868-3p ; hsa-mir-4778-3p ; hsa-mir-942-5p ; hsa-mir-1236-3p ; hsa-mir-6515-3p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-1248 ; hsa-mir-3163 ; hsa-mir-513c-3p ; hsa-mir-513a-3p ; hsa-mir-3606-3p ; hsa-mir-4282 ; hsa-mir-4446-5p ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-4652-3p ; hsa-mir-544a ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-548aw ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-623 ; hsa-mir-1468-3p ; hsa-mir-548x-5p ; hsa-mir-548g-5p ; hsa-mir-548f-5p ; hsa-mir-548aj-5p ; hsa-mir-539-5p ; hsa-mir-627-3p ; hsa-mir-3124-3p ; hsa-mir-3182 ; hsa-mir-2276-3p ; hsa-mir-4772-3p ; hsa-mir-1237-3p ; hsa-mir-5088-3p ; hsa-mir-548c-3p

Nearest miRNA

hsa-mir-10226/Upstream/121578; hsa-mir-1250/Downstream/1136172;

Nearest TSS

ENST00000595228/Upstream/13174; ENST00000512720/Downstream/14144;

Nearest CpG islands

None/Target, chr17-CpG: 26/Upstream/55471, chr17-CpG: 65/Downstream/45030

Nearest cancer related gene

SPOP(TSG, No orient, 0)

Upstream sequence

ACAATAGTGAGAAAAGTACATTTCCCAGAATAAGTCAATCCTGGTTATAGAAGTACCATTACAGCAGCTGTCAGGAACCCAAGCTAAACTCTTAAGTTAT

Downstream sequence

TTCAAGTTAAAttcttctttttttttttttccagacagagtttcattcttgttgcccaggctggagtgcaatggcatggtctcggctcactgcaacctcc

Target sequence

TCAGGAACCCAAGCTAAACTCTTAAGTTAT

Reference

Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.