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TVIS30015524
Basic Information
VIS ID
TVIS30015524
Fusion event
HIV-SRSF1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q22
Reference genome
GRCh37/hg19
Start
56080489/58003128 (Hg38)
End
56080372/58003128 (Hg38)
Orient
-
Location type
Exonic
Fragile sites / regions
FRA17B
Target gene
SRSF1
miRNAs that regulate target gene
hsa-mir-7-5p
;
hsa-mir-10a-5p
;
hsa-mir-10b-5p
;
hsa-mir-505-3p
;
hsa-mir-103a-3p
;
hsa-mir-16-5p
;
hsa-mir-744-5p
;
hsa-mir-193b-3p
;
hsa-mir-423-3p
;
hsa-mir-149-5p
;
hsa-mir-335-3p
;
hsa-mir-5692c
;
hsa-mir-5692b
;
hsa-mir-607
;
hsa-mir-1305
;
hsa-mir-4709-3p
;
hsa-mir-155-5p
;
hsa-mir-6516-5p
;
hsa-mir-455-3p
;
hsa-mir-7847-3p
;
hsa-mir-6880-5p
;
hsa-mir-6745
;
hsa-mir-363-5p
;
hsa-mir-608
;
hsa-mir-4651
;
hsa-mir-6851-5p
;
hsa-mir-3689d
;
hsa-mir-6499-3p
;
hsa-mir-6086
;
hsa-mir-6823-3p
;
hsa-mir-377-5p
;
hsa-mir-2114-3p
;
hsa-mir-7113-5p
;
hsa-mir-4762-5p
;
hsa-mir-6782-5p
;
hsa-mir-6837-5p
;
hsa-mir-4685-5p
;
hsa-mir-6715a-3p
;
hsa-mir-7843-5p
;
hsa-mir-6879-5p
;
hsa-mir-6735-5p
;
hsa-mir-4632-5p
;
hsa-mir-4436b-3p
;
hsa-mir-6753-5p
;
hsa-mir-377-3p
;
hsa-mir-466
;
hsa-mir-4672
;
hsa-mir-3941
;
hsa-mir-4653-3p
;
hsa-mir-4424
;
hsa-mir-622
;
hsa-mir-6514-5p
;
hsa-mir-4802-5p
;
hsa-mir-4801
;
hsa-mir-4731-3p
;
hsa-mir-338-5p
;
hsa-mir-5583-5p
;
hsa-mir-3129-3p
;
hsa-mir-216a-3p
;
hsa-mir-128-3p
;
hsa-mir-27a-3p
;
hsa-mir-27b-3p
;
hsa-mir-3681-3p
;
hsa-mir-552-5p
;
hsa-mir-6792-5p
;
hsa-mir-107
;
hsa-mir-6838-5p
;
hsa-mir-497-5p
;
hsa-mir-424-5p
;
hsa-mir-195-5p
;
hsa-mir-15b-5p
;
hsa-mir-15a-5p
;
hsa-mir-1255b-2-3p
;
hsa-mir-6776-3p
;
hsa-mir-33a-3p
;
hsa-mir-4452
;
hsa-mir-183-3p
;
hsa-mir-508-3p
;
hsa-mir-4724-5p
;
hsa-mir-6734-3p
;
hsa-mir-3667-3p
;
hsa-mir-34c-3p
;
hsa-mir-500a-5p
;
hsa-mir-34b-3p
;
hsa-mir-4668-3p
;
hsa-mir-548c-3p
;
hsa-mir-9-5p
;
hsa-mir-1227-3p
;
hsa-mir-25-5p
;
hsa-mir-4252
;
hsa-mir-4459
;
hsa-mir-4537
;
hsa-mir-508-5p
;
hsa-mir-550b-2-5p
;
hsa-mir-6087
;
hsa-mir-658
;
hsa-mir-766-3p
;
hsa-mir-5186
Nearest miRNA
hsa-mir-10226/Upstream/1111773; hsa-mir-1250/Downstream/328104;
Nearest TSS
ENST00000595228/Upstream/8278;
ENST00000579991/Downstream/2006;
Nearest CpG islands
None/Target,
chr17-CpG: 26/Upstream/14438
,
chr17-CpG: 139/Downstream/3315
Nearest cancer related gene
SRSF1
(OG, No orient, 0)
Upstream sequence
CTAATACATCTGTGCTGATGTTAACATTTAATACTTACCTTTTTTTGAGATGAGTTTCATTGAGAATATCAAAAGCTATCTCCAAGTGAACATTAGTAGC
Downstream sequence
CATCAACCAATTTTGCACAAAAGCCTATGTTGTCTATGACCACCAGAAAATAAGCAGCATCTATAGTTTTTTAACCACTTTATAACAAAGTAGAGAAGCT
Target sequence
aaaaacaaaaaaCAGTTCTAATACATCTGTGCTGATGTTAACATTTAATACTTACCTTTTTTTGAGATGAGTTTCATTGAGAATATCAAAAGCTATCTCCAAGTGAACATTAGTAGC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Sample Information
×
Sample name
PT1
Sample type
PBMC
Age
47
Gender
Male
CpG Island Information
×
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