Basic Information
VIS ID
TVIS30015532
Fusion event
HIV-ERN1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
62141029/64063669 (Hg38)
End
62140912/64063669 (Hg38)
Orient
-
Location type
Intronic
Target gene
ERN1
miRNAs that regulate target gene
hsa-let-7a-5p ; hsa-mir-199a-5p ; hsa-mir-1291 ; hsa-mir-192-3p ; hsa-mir-107 ; hsa-mir-103a-3p ; hsa-mir-219b-3p ; hsa-mir-1184 ; hsa-mir-451b ; hsa-mir-186-5p ; hsa-mir-4539 ; hsa-mir-7158-3p ; hsa-mir-649 ; hsa-mir-490-3p ; hsa-mir-6749-3p ; hsa-mir-4680-5p ; hsa-mir-5193 ; hsa-mir-4667-3p ; hsa-mir-6887-3p ; hsa-mir-7157-5p ; hsa-mir-4310 ; hsa-mir-665 ; hsa-mir-1273e ; hsa-mir-6771-5p ; hsa-mir-7160-5p ; hsa-mir-4722-5p ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-1827 ; hsa-mir-4649-3p ; hsa-mir-6746-5p ; hsa-mir-4768-3p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-302f ; hsa-mir-6891-5p ; hsa-mir-3173-3p ; hsa-let-7a-2-3p ; hsa-let-7g-3p ; hsa-mir-3612 ; hsa-mir-4459 ; hsa-mir-4687-3p ; hsa-mir-4695-5p ; hsa-mir-4700-3p ; hsa-mir-5582-5p ; hsa-mir-650
Nearest miRNA
hsa-mir-10226/Upstream/1119357; hsa-mir-1250/Downstream/437105;
Nearest TSS
ENST00000595228/Upstream/8902; ENST00000580828/Downstream/3315;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/64568, chr17-CpG: 143/Downstream/65840
Upstream sequence
AACCCCTCACCCTCATGCCCACGTGGACTCCAAGTTAATTCTTCCATAGAAACagtctcagttttcttaactataaaatggaaatgacaagggtacctac
Downstream sequence
ctcacacagggttgctgtgaggagtgaggaaatgcattctaaagggcttaATGTCGGATACTCACACAAGGTTTACATTAATTTAGTACCTGAGTTTTGG
Target sequence
TCAGCCCTCGCCTCTCCAACCCCTCACCCTCATGCCCACGTGGACTCCAAGTTAATTCTTCCATAGAAACagtctcagttttcttaactataaaatggaaatgacaagggtacctac
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate