Basic Information
VIS ID
TVIS30015534
Fusion event
HIV-HELZ integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
65094293/67098177 (Hg38)
End
65094151/67098177 (Hg38)
Orient
-
Location type
Intronic
Target gene
HELZ
miRNAs that regulate target gene
hsa-mir-103a-3p ; hsa-mir-16-5p ; hsa-mir-130b-5p ; hsa-mir-186-5p ; hsa-mir-203a-3p ; hsa-mir-4635 ; hsa-mir-8084 ; hsa-mir-4282 ; hsa-mir-25-5p ; hsa-mir-377-5p ; hsa-mir-4252 ; hsa-mir-4459 ; hsa-mir-4537 ; hsa-mir-455-3p ; hsa-mir-6086 ; hsa-mir-6499-3p ; hsa-mir-6516-5p ; hsa-mir-658
Nearest miRNA
hsa-mir-10226/Upstream/311009; hsa-mir-1250/Downstream/373312;
Nearest TSS
ENST00000595228/Upstream/53587; ENST00000583452/Downstream/90184;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/53264, chr17-CpG: 158/Downstream/146432
Upstream sequence
AATTTTACACAACTGAAGATTGAATTCTTCACAAGAACATAATTTTGCTTTTCCCCCACATCTAGTTCTGTGTAATTGCAATCATTTCTCATTTTCTAAG
Downstream sequence
AATAAACCTTACTCATGGAATAGAGATCTGAAGAgcagtgtgatgcttcagaaacagcatgggactgtcaggagtctccactcccttgagttaataactg
Target sequence
CTAGCTCCCTTTCTCCCCACCACCCAGAAAAAATAAAAGGCAAATTTTACACAACTGAAGATTGAATTCTTCACAAGAACATAATTTTGCTTTTCCCCCACATCTAGTTCTGTGTAATTGCAATCATTTCTCATTTTCTAAG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate