Basic Information
VIS ID
TVIS30015538
Fusion event
HIV-JPT1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
73144870/75148775 (Hg38)
End
73144947/75148775 (Hg38)
Orient
+
Location type
Intronic
Target gene
JPT1
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-106b-5p ; hsa-mir-17-5p ; hsa-mir-3187-3p ; hsa-mir-132-3p
Nearest miRNA
hsa-mir-10226/Upstream/400076; hsa-mir-1250/Downstream/257294;
Nearest TSS
ENST00000595228/Upstream/1995; ENST00000582833/Downstream/4518;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/16875, chr17-CpG: 115/Downstream/4763
Upstream sequence
AAATAATGGCAAAACATCAACTTCAGATCATACTGAAACATTTCTTGGCATAAATCTTTTCAGACAACTTTCATTTCACTTTCCTCACCCATTCATCTCC
Downstream sequence
AAGATACTAAATACTGCTTTATAATACTTGTAATAAGGTCATCGATCACACAAGGCAGCTGAAACAGCATGGAACTCATCATAAATAACAGCCTGGTTGG
Target sequence
CTCACCCCTACAACAGATAGCTGCTAACAGGAAAAAAGAATCAACTCCATCAGTGTCTACATTCAGTGCTGGATGTT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate