Basic Information
VIS ID
TVIS30015542
Fusion event
HIV-TMEM94 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
73480401/75484320 (Hg38)
End
73480291/75484320 (Hg38)
Orient
-
Location type
Intronic
Target gene
TMEM94
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-24-3p ; hsa-mir-877-3p ; hsa-mir-193b-3p ; hsa-mir-181a-5p ; hsa-mir-181b-5p ; hsa-mir-181c-5p ; hsa-mir-181d-5p ; hsa-mir-4262 ; hsa-mir-15a-3p ; hsa-mir-4308 ; hsa-mir-4292 ; hsa-mir-3657 ; hsa-mir-6791-5p ; hsa-mir-7855-5p ; hsa-mir-4710 ; hsa-mir-4316 ; hsa-mir-4792 ; hsa-mir-6089 ; hsa-mir-5008-5p ; hsa-mir-4299
Nearest miRNA
hsa-mir-10226/Upstream/78158; hsa-mir-1250/Downstream/14228;
Nearest TSS
ENST00000595228/Upstream/7630; ENST00000584383/Downstream/1076;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/78413, chr17-CpG: 22/Downstream/17698
Upstream sequence
ttacaatatcctctctttcatgaaatggtagttatagaagatggtgggttttttccctccctgcccctttcttccgtccctccctccctccctcccaacc
Downstream sequence
tccctccctccctGACAGAGCTGGAAGGTTTTTTTCCTTCATGTCTTTCCTAGGAACAGTGAAATGCTAGCAtctcttttttgttgttgtttttttgaga
Target sequence
tgtttcagtgttacaatatcctctctttcatgaaatggtagttatagaagatggtgggttttttccctccctgcccctttcttccgtccctccctccctccctcccaacc
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate