Basic Information
VIS ID
TVIS30015562
Fusion event
HIV-CYTH1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
76757796/78761714 (Hg38)
End
76758002/78761714 (Hg38)
Orient
+
Location type
Intronic
Target gene
CYTH1
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-335-5p ; hsa-mir-26b-5p ; hsa-mir-34a-5p ; hsa-mir-1827 ; hsa-mir-3940-3p
Nearest miRNA
hsa-mir-10226/Upstream/1364660; hsa-mir-1250/Downstream/945462;
Nearest TSS
ENST00000595228/Upstream/24747; ENST00000587434/Downstream/20558;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/258721, chr17-CpG: 155/Downstream/19714
Upstream sequence
gtagtcccagctacttgggaggctgaggcaggagaatgacgtgaacccgggaggcggagcttgcagtgagacgagatcacgccactgcactccagcctgg
Downstream sequence
AGTGGAAATTAAACCAAATGAGCCTTTAACATAAACGTTTGAAAGAGTAACAGCATCTGGCCTGCTTCCTCCATACAATGAGGTGTCCATCATGTGACAT
Target sequence
gggacagagcgagactccgtctcaaaaacaaaaaaaaaaGAGTGTTATTTTTAAAAACTTTTTAAAGCTTAAATTCCTCTTATTAGAATGCTATACACACACATTTATACGTTTGAGAAAACAGTAGTCCAAAGCAAGAGCAGGAAAGGGAAAGAACAGTAGTAGTCAGCTAGACATTTGGTTTTGTATCCTTAACATCTATTCTG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate