Basic Information
VIS ID
TVIS30015566
Fusion event
HIV-RPTOR integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
78618181/80644381 (Hg38)
End
78618043/80644381 (Hg38)
Orient
-
Location type
Intronic
Target gene
RPTOR
miRNAs that regulate target gene
hsa-mir-27b-3p ; hsa-mir-27a-3p ; hsa-mir-155-5p
Nearest miRNA
hsa-mir-10226/Upstream/224888; hsa-mir-1250/Downstream/480895;
Nearest TSS
ENST00000595228/Upstream/98715; ENST00000572733/Downstream/64552;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/99098, chr17-CpG: 30/Downstream/82646
Upstream sequence
GAGCCAGTTACCAATTAGTGTGTGGGTTTTTTTTTTTTTTTTTTTGGCTTATATCTTACAGTTTTTTGTTTGTTTGTTTAAAGAAAAGTGGCTTAGAATA
Downstream sequence
TAACTGTGTCAAATTGCCTTTAAGATCTTAAGTTACTTGTAATCCACCCAAAGACCTTTAGCCTTTCTTATTAACTGGTTTGGAGatttaataaatttaa
Target sequence
GCTTTGCCTTTGATTCAAAAGATAAGGTTCTTTTTAGGGAGCCAGTTACCAATTAGTGTGTGGGTTTTTTTTTTTTTTTTTTTGGCTTATATCTTACAGTTTTTTGTTTGTTTGTTTAAAGAAAAGTGGCTTAGAATA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate