Basic Information
VIS ID
TVIS30015586
Fusion event
HIV-NARF integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
80432093/82474217 (Hg38)
End
80432376/82474217 (Hg38)
Orient
+
Location type
Intronic
Target gene
NARF
miRNAs that regulate target gene
hsa-mir-98-5p ; hsa-mir-24-3p ; hsa-mir-16-5p ; hsa-mir-423-3p ; hsa-mir-6516-5p ; hsa-mir-455-3p ; hsa-mir-650 ; hsa-mir-3612 ; hsa-mir-6499-3p ; hsa-mir-6086 ; hsa-mir-2467-3p ; hsa-mir-377-5p ; hsa-mir-4487 ; hsa-mir-1827 ; hsa-mir-558 ; hsa-mir-3160-3p ; hsa-mir-5186 ; hsa-mir-4257 ; hsa-mir-1247-3p ; hsa-mir-6511a-5p ; hsa-mir-1910-3p ; hsa-mir-4325 ; hsa-mir-7703 ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-766-3p ; hsa-mir-6849-3p ; hsa-mir-92b-3p ; hsa-mir-92a-3p ; hsa-mir-367-3p ; hsa-mir-363-3p ; hsa-mir-32-5p ; hsa-mir-25-3p ; hsa-mir-508-5p
Nearest miRNA
hsa-mir-10226/Upstream/237489; hsa-mir-4525/Downstream/194016;
Nearest TSS
ENST00000595228/Upstream/5718; ENST00000584513/Downstream/3707;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/14834, chr17-CpG: 111/Downstream/22559
Upstream sequence
ctgcagtgagctatgactcctccattgtactccagcctgggcgaaagactgaggtcctgtctcttaagaaaaTCCGTTTTCTCTTGAAAGTACAACATAT
Downstream sequence
TAAAAATTATTCTACTACATGAGGCCTGTGGGAGCATAGGAGAGCTCTATCTAAGCTAGTCGTAGGCTGTATAATTTTTAGGGTTTGGTTCACGTTTCAG
Target sequence
CTCAGATGTACAAATAATTATGGAATAATATGGCAAACGTGCATGTATCTTTTGCCAGCTTAAAAAAAATACAGAATAAGAAAATTTCTTTACATTGATATTCAGATACTCTCAGGGCGCACTGTTTAAACCACTCTTTAATTGGTTTTTGGATGCCTGAGTTATAGAAGAGATTTGTCACATGCTTTTCAATTCTGGAAAAATAGAGAGTTTGGGTTAAGAAATCTTCGATGATGCATAAGGGAATAAGGAAGG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate