Basic Information
VIS ID
TVIS30015597
Fusion event
HIV-ANKRD12 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
p11.22
Reference genome
GRCh37/hg19
Start
9207228/9207230 (Hg38)
End
9207200/9207230 (Hg38)
Orient
-
Location type
Intronic
Target gene
ANKRD12
miRNAs that regulate target gene
hsa-mir-342-5p ; hsa-mir-365a-3p ; hsa-mir-17-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-374a-5p ; hsa-mir-155-5p ; hsa-mir-1273e ; hsa-mir-3692-3p ; hsa-mir-140-3p ; hsa-mir-144-3p
Nearest miRNA
hsa-mir-3976/Upstream/2832805; hsa-mir-1-2/Downstream/1552354;
Nearest TSS
ENST00000575820/Upstream/24844; ENST00000359158/Downstream/9550;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/69634, chr18-CpG: 134/Downstream/126668
Upstream sequence
ACCAAGATATGCAGAAAATTAGGAGAAAAAATCCATATATGCTTCAGGAAAAAATTGGCTTCTCCAAAAATCTGTTTAGGGCTTTATAATGCAGCGTAAG
Downstream sequence
TTAGGAAAAGTACTGTGCTAAGATTGGATTTATGCTAAATTGGATCATTAATGATAATGAAATAATAAATATGAAAAGATTATACTGGAAAAAAATAAAG
Target sequence
TGTTTAGGGCTTTATAATGCAGCGTAAG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate