Basic Information
VIS ID
TVIS30015614
Fusion event
HIV-MEX3C integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
48720660/51194290 (Hg38)
End
48720801/51194290 (Hg38)
Orient
+
Location type
Intronic
Target gene
MEX3C
miRNAs that regulate target gene
hsa-mir-374b-5p ; hsa-mir-103a-3p ; hsa-mir-744-5p ; hsa-mir-155-5p ; hsa-mir-4659a-3p ; hsa-mir-4659b-3p ; hsa-mir-4724-5p ; hsa-mir-4793-5p ; hsa-mir-5196-3p ; hsa-mir-6875-3p ; hsa-mir-8064
Nearest miRNA
hsa-mir-1-2/Upstream/1067727; hsa-mir-122/Downstream/2042811;
Nearest TSS
ENST00000575820/Upstream/117039; ENST00000578152/Downstream/2469;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/163327, chr18-CpG: 156/Downstream/1870
Upstream sequence
ACTATGCTGCTGGGACATGGGGGTGGCAAAGGGGTCAATGATCCACAAGTTGTATGGTTCAGAACAGCAAAAGGACCAGATTTTCTGCTTTTAAGATAGA
Downstream sequence
AAGAAAAACTAAGGCTTTATCTCATTTCCTATCACGTAATAGCTGGTACAAAATAAAAACTTGGAATTCACTTTACTTTTAAAAAACTGATTTCTATAAA
Target sequence
GGATGATGACATACTTTTAACAGTATTGTCAACTCTGGGAAAATACAAGGTTTAAATGGAAGAGCCAGCAATTTGTCTCCATGATCTAAGACATAATTAAATTCAACATTTCCTTATTAACCAAATAAACACAGCCCTCAA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate