Basic Information
VIS ID
TVIS30015615
Fusion event
HIV-ATP8B1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q21.31
Reference genome
GRCh37/hg19
Start
55394951/57727719 (Hg38)
End
55394971/57727719 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA18B
Target gene
ATP8B1
miRNAs that regulate target gene
hsa-mir-5096 ; hsa-mir-6855-5p ; hsa-mir-3170 ; hsa-mir-197-3p ; hsa-mir-6832-5p ; hsa-mir-193b-5p ; hsa-mir-762 ; hsa-mir-4498 ; hsa-mir-5001-5p ; hsa-mir-4492 ; hsa-mir-4743-5p ; hsa-mir-1273f ; hsa-mir-4716-5p ; hsa-mir-4781-3p ; hsa-mir-6890-5p ; hsa-mir-3692-3p ; hsa-mir-140-3p ; hsa-mir-181d-5p ; hsa-mir-4262 ; hsa-mir-181b-5p ; hsa-mir-181c-5p ; hsa-mir-181a-5p
Nearest miRNA
hsa-mir-1-2/Upstream/2248421; hsa-mir-122/Downstream/723355;
Nearest TSS
ENST00000575820/Upstream/19161; ENST00000586729/Downstream/4088;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/79019, chr18-CpG: 168/Downstream/74105
Upstream sequence
ctctactaaaaatacaaaaattagccaggcgtggtagcatacgcctgtaatcccagctacttgggaggctgaggcaggagaatcgcttgaacccaggagc
Downstream sequence
tcgcgcctctgctctccagtctgggcgacagagagagactccatctcaaaacaaaaacaaacaaacaaaCAACAAGAAAACTCCAAAAATACAAAAACTA
Target sequence
ggggttgcagtgagccgata
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate