Basic Information
VIS ID
TVIS30015616
Fusion event
HIV-chr18 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q21.32
Reference genome
GRCh37/hg19
Start
58523446/60856213 (Hg38)
End
58523571/60856213 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA18B
Nearest miRNA
hsa-mir-1-2/Upstream/2405055; hsa-mir-5011/Downstream/6225371;
Nearest TSS
ENST00000575820/Upstream/483438; ENST00000587582/Downstream/46513;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/886318, chr18-CpG: 98/Downstream/477237
Nearby gene
MC4R(No orient, 483445)
Upstream sequence
gtgctgggattacagatataagccatggcactggccCAAAGCCAGTAAGAATTTTTTCAGGACAAACTGGAAAGTGTAACCAAGATGAAAATGAATGCCA
Downstream sequence
CTAGGAAGACTTCGGGTTGCCAAGACAAGGAGAGCAGATGGGTAGTGCTGGTTAAAAAACGAGGGCCCTGGGTCAATTTCAGAAGAGTTAGATACCAAGA
Target sequence
GTCATTGTGCATCACTGTCCTGGCTCAGGCAGGTGTGAGCATTACTTGGCATTTGGGCTTTCTAAAGCTCGGAGCCCATGGGAACTGGAGGAGGAAGTTCCCACCAAGCAAAGTGGTTCAGGCAC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate