Basic Information
VIS ID
TVIS30015617
Fusion event
HIV-VPS4B integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q21.33
Reference genome
GRCh37/hg19
Start
61080947/63413714 (Hg38)
End
61080908/63413714 (Hg38)
Orient
-
Location type
Intronic
Target gene
VPS4B
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-128-3p ; hsa-mir-124-3p ; hsa-mir-32-5p ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-125b-5p ; hsa-mir-526b-5p ; hsa-mir-6881-3p ; hsa-mir-6780a-3p ; hsa-mir-7111-3p ; hsa-mir-5186 ; hsa-mir-6730-5p ; hsa-mir-5681a ; hsa-mir-877-3p ; hsa-mir-935 ; hsa-mir-5094 ; hsa-mir-548m ; hsa-mir-367-3p ; hsa-mir-92a-3p ; hsa-mir-25-3p ; hsa-mir-363-3p ; hsa-mir-92b-3p ; hsa-mir-216a-3p ; hsa-mir-3681-3p ; hsa-mir-488-3p
Nearest miRNA
hsa-mir-1-2/Upstream/4962556; hsa-mir-5011/Downstream/3667870;
Nearest TSS
ENST00000575820/Upstream/9000; ENST00000424602/Downstream/8676;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/45891, chr18-CpG: 84/Downstream/8315
Upstream sequence
GGGTTAATTTAGGTAGTAAAACTATTCAACAGAAATAGGTGCCAGTAAAAAAAAATGAAAATTGACAGTTGTTAGAGATATTAAAAAGTAAGTATATAAC
Downstream sequence
ATAAGCAAAAAATCATTCAAACAATGCAAAAACCAATTATGTGTAAGAATATTACATTTTGGGGCAGTTGAGCATGGATTGGATATAACTGGGCTGAGAT
Target sequence
TTGACAGTTGTTAGAGATATTAAAAAGTAAGTATATAAC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate