Basic Information
VIS ID
TVIS30015621
Fusion event
HIV-ZNF236 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q23
Reference genome
GRCh37/hg19
Start
74603220/76891264 (Hg38)
End
74603287/76891264 (Hg38)
Orient
+
Location type
Intronic
Target gene
ZNF236
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-142-3p ; hsa-mir-132-3p ; hsa-mir-128-3p ; hsa-let-7e-5p ; hsa-mir-4732-5p ; hsa-mir-4668-5p ; hsa-mir-3148 ; hsa-mir-6783-5p ; hsa-mir-548n ; hsa-mir-6872-3p ; hsa-mir-670-3p ; hsa-mir-6836-3p ; hsa-mir-7162-5p ; hsa-mir-516b-3p ; hsa-mir-516a-3p ; hsa-mir-2115-5p ; hsa-mir-222-3p ; hsa-mir-221-3p ; hsa-mir-6829-3p ; hsa-mir-6791-3p ; hsa-mir-6778-3p ; hsa-mir-1976 ; hsa-mir-4797-3p ; hsa-mir-6893-3p ; hsa-mir-370-3p ; hsa-mir-660-3p
Nearest miRNA
hsa-mir-1-2/Upstream/4037882;
Nearest TSS
ENST00000575820/Upstream/10982; ENST00000584565/Downstream/6828;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/67315, chr18-CpG: 23/Downstream/3723
Upstream sequence
taacctccgagttgttcaagggtcagttgTACATTTTTTTCTAATTTGTTTGCCTTTTTGAGCTGAAAAACTTTTTTAACTGGGGAAATATTTATTTATA
Downstream sequence
ATTATGGAAAGATAACCTCTTCTCTTATATCTGACTTTTATAATTTAATAGGttttttttttcgagacagggtctctgttgcccaggctgcagtgtggtg
Target sequence
TGTATAGCTAAGTTTGTCAATGTTTAATGACTTTAGGCTTGGGTGATATTTAGACTTCATCACTGAC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate