Basic Information
VIS ID
TVIS30015624
Fusion event
HIV-chr19 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
1190295/1190296 (Hg38)
End
1190127/1190296 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA19B
Nearest miRNA
hsa-mir-1302-11/Upstream/376643; hsa-let-7e/Downstream/625863;
Nearest TSS
ENST00000633603/Upstream/12738; ENST00000593219/Downstream/15509;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/15952, chr19-CpG: 47/Downstream/4166
Nearby gene
STK11(No orient, 15502)
Nearest cancer related gene
STK11(TSG, No orient, 15502)
Upstream sequence
GGggctggggatggtggcccacacctgtgtttgcagcactttgggaggctgaggcaggaggatcactagagcccaagagttcaagatcagcctggcctac
Downstream sequence
aaaaaaatatttaaaaatttgctgggtgtgggaggctgaagtcagaggatcacctgagcccagggagttggaggctgcagtgagcggtaatcatgccact
Target sequence
TCCATGGGGAGGAGCCTTTGAGGTGGCAGGAGGGAACCAGTCCTGATGAGGGAAGATTAAAGGACAGTGGggctggggatggtggcccacacctgtgtttgcagcactttgggaggctgaggcaggaggatcactagagcccaagagttcaagatcagcctggcctac
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate