Basic Information
VIS ID
TVIS30015625
Fusion event
HIV-HMGB2P1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
1203468/1203469 (Hg38)
End
1203304/1203469 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
HMGB2P1
Nearest miRNA
hsa-mir-1302-11/Upstream/389816; hsa-let-7e/Downstream/612690;
Nearest TSS
ENST00000633603/Upstream/25911; ENST00000593219/Downstream/2336;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/8605, chr19-CpG: 231/Downstream/1900
Nearby gene
STK11(No orient, 2329)
Upstream sequence
AAAGGAGAAGTGAAGTTTGAAGAGAAGGCAAAAAGTGACAAAGCTCGCTGTGACAGGGAGATTAAAAATTACATTCCTCCGAAATGTAAGAAAGGGTAAG
Downstream sequence
AAAGGAAAGAAAAAGGATCGCAATGCTCCTAGAAGGCCACCATCTGCCTTCTTCCTGTTTTGCTCTGAACATCGCCCAAAGATCAAAAGTGGACACCCAG
Target sequence
ACTCTTCTGTCAATTTCGTGGAATTCTCCAAGAAGTGTTTGGAGAGATGGAAGACCACGTCTGCAAAGGAGAAGTGAAGTTTGAAGAGAAGGCAAAAAGTGACAAAGCTCGCTGTGACAGGGAGATTAAAAATTACATTCCTCCGAAATGTAAGAAAGGGTAAG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate