Basic Information
VIS ID
TVIS30015626
Fusion event
HIV-STK11 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
1218050/1218051 (Hg38)
End
1218000/1218051 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
STK11
miRNAs that regulate target gene
hsa-mir-130b-3p ; hsa-mir-93-5p ; hsa-mir-17-5p ; hsa-mir-199a-3p ; hsa-mir-6795-5p ; hsa-mir-6887-5p ; hsa-mir-7111-5p ; hsa-mir-6870-5p ; hsa-mir-5698 ; hsa-mir-4723-5p ; hsa-mir-6825-5p ; hsa-mir-6829-5p ; hsa-mir-6785-5p ; hsa-mir-6883-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-604 ; hsa-mir-4721 ; hsa-mir-6890-3p ; hsa-mir-4446-3p ; hsa-mir-4767 ; hsa-mir-873-5p ; hsa-mir-3141 ; hsa-mir-7-5p ; hsa-mir-150-5p ; hsa-mir-3943 ; hsa-mir-4530 ; hsa-mir-4660 ; hsa-mir-4715-3p ; hsa-mir-4722-3p ; hsa-mir-500b-3p ; hsa-mir-646 ; hsa-mir-6727-3p ; hsa-mir-6736-3p ; hsa-mir-6752-3p ; hsa-mir-6801-3p ; hsa-mir-6810-3p ; hsa-mir-6856-3p
Nearest miRNA
hsa-mir-1302-11/Upstream/404398; hsa-let-7e/Downstream/598108;
Nearest TSS
ENST00000633603/Upstream/10960; ENST00000591133/Downstream/1962;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/10628, chr19-CpG: 29/Downstream/2435
Nearest cancer related gene
STK11(TSG, No orient, 0)
Upstream sequence
ggccaacatggtgaaaccctgtctgtactaaaatacaaaaaaattagccggctgtggtgacacgtgcctgtagtcccagctactcgggaggctgaggcag
Downstream sequence
ggaaatcacttgaacctgggaggcagaggttgcagtgagctgagatcgggccaccgtgctccagcctagggacagagcaagactctgtctcagaaaaaaa
Target sequence
gctgtggtgacacgtgcctgtagtcccagctactcgggaggctgaggcag
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate