Basic Information
VIS ID
TVIS30015629
Fusion event
HIV-BTBD2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
2006221/2006222 (Hg38)
End
2006403/2006222 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
BTBD2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-33a-5p ; hsa-mir-32-5p ; hsa-mir-324-5p ; hsa-mir-20a-5p ; hsa-mir-16-5p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-1302-11/Upstream/189984; hsa-let-7e/Downstream/227840;
Nearest TSS
ENST00000633603/Upstream/8798; ENST00000481489/Downstream/9320;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/6889, chr19-CpG: 34/Downstream/9274
Upstream sequence
CTAAGAGTCCAAGGGGTCAATactagacacacatggctatttaaatctatatccaaattcagctgaattcaacattcaactcctcggtcacactgtccac
Downstream sequence
gctgaggcaggagaatcacttgaacccaggaagcggagcttgcagtgagctgacactgtgccactgcactccagcctgggcgacagagcgagactccgtc
Target sequence
atctgtagtccgtactggcacatgagtgcctagtattggacagcacacatccaaaccatcccgcttactacaggatactctactgcagagcacAAGACCACAGAAAAACTGTTAAACCTAATAAGGCTTCAGGAAGAAACAGTTCAAACCAGATAAAAGTAAACatgccagctactcgggag
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate