Basic Information
VIS ID
TVIS30015633
Fusion event
HIV-GNG7 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
2592121/2592123 (Hg38)
End
2592253/2592123 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
GNG7
miRNAs that regulate target gene
hsa-mir-92a-3p ; hsa-mir-3925-5p ; hsa-mir-4311 ; hsa-mir-4524a-3p
Nearest miRNA
hsa-mir-1227/Upstream/157123; hsa-let-7e/Downstream/38592;
Nearest TSS
ENST00000633603/Upstream/115767; ENST00000592525/Downstream/39831;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/3531, chr19-CpG: 18/Downstream/15604
Upstream sequence
tcaatgattaacagaattgtaaatgccactatcttctaaagctgcatttctgcttttaggaatttacctcctgagatatttagacaaggtcaaaagtgat
Downstream sequence
GATCACACTGACAAAAAATGGCAACCAAAAACAACTCTTAACATTTTTCAAAAGGCTGAAAAGTAGAGTTGCTACATTAAAAAAAAATTGCTCCTTCTAT
Target sequence
gtataccatgatgtttctgctgcaacattatttggatgtaagaaaaactgtaaagatcagtagtgtgttcttcaagtcactctggcatatccatacacaagaacgcgctaactaaaaagaatgaagCTCACT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
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