VISDB - VIS Detail

Basic Information

VIS ID

TVIS30015637

Fusion event

HIV-FZR1 integration

Validated

Yes

Detection method

LM PCR

Data source

Curated

Sample type

PBMC

Disease

HIV-infected disease (HID)

Quality evaluation

Good

Reported year

2014

PubMed ID

24968937

Virus Sequence

Virus name

HIV

Reference genome

Not given

Host Sequence

Chromosome

chr19

Cytoband

p13.3

Reference genome

GRCh37/hg19

Start

3534312/3534314 (Hg38)

End

3534376/3534314 (Hg38)

Orient

Location type

Intronic

Fragile sites / regions

FRA19B

Target gene

FZR1

miRNAs that regulate target gene

hsa-mir-744-5p ; hsa-mir-4711-5p ; hsa-mir-4639-5p ; hsa-mir-4793-5p ; hsa-mir-5196-3p ; hsa-mir-4328 ; hsa-mir-7157-5p ; hsa-mir-4310 ; hsa-mir-29b-2-5p ; hsa-mir-4763-3p ; hsa-mir-1207-5p ; hsa-mir-605-3p ; hsa-mir-6823-5p ; hsa-mir-296-3p ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-3714 ; hsa-mir-1293 ; hsa-mir-1976 ; hsa-mir-214-3p ; hsa-mir-23a-5p ; hsa-mir-23b-5p ; hsa-mir-34a-5p ; hsa-mir-34c-5p ; hsa-mir-3619-5p ; hsa-mir-363-5p ; hsa-mir-3653-5p ; hsa-mir-3925-3p ; hsa-mir-4277 ; hsa-mir-4279 ; hsa-mir-4436b-3p ; hsa-mir-4468 ; hsa-mir-4483 ; hsa-mir-449a ; hsa-mir-449b-5p ; hsa-mir-4632-5p ; hsa-mir-4685-5p ; hsa-mir-541-3p ; hsa-mir-584-3p ; hsa-mir-6510-5p ; hsa-mir-6512-3p ; hsa-mir-654-5p ; hsa-mir-6720-5p ; hsa-mir-6735-5p ; hsa-mir-6742-5p ; hsa-mir-6745 ; hsa-mir-6748-5p ; hsa-mir-6756-5p ; hsa-mir-6766-5p ; hsa-mir-6769a-5p ; hsa-mir-6769b-5p ; hsa-mir-6814-5p ; hsa-mir-6837-5p ; hsa-mir-6849-3p ; hsa-mir-6879-5p ; hsa-mir-761 ; hsa-mir-766-3p ; hsa-mir-7843-5p ; hsa-mir-92a-2-5p

Nearest miRNA

hsa-mir-1227/Upstream/903521; hsa-let-7e/Downstream/427100;

Nearest TSS

ENST00000633603/Upstream/29; ENST00000329493/Downstream/4840;

Nearest CpG islands

None/Target, chr19-CpG: 112/Upstream/1646, chr19-CpG: 20/Downstream/11832

Nearest cancer related gene

FZR1(TSG, No orient, 0)

Upstream sequence

ccgtcttaaaattaaaaaaaaaaaaaaaaaaaaGGCTCCAACCTTGGTTTCTGCTTGTGGTGGCCCCAGCCTGCCCCTCCCTCCTGGCTCCAGAGTCTGG

Downstream sequence

CTAGAGGCCCAGAGACATGGGGTGCTTCCCTCCTGTCCACAGGCAATGTCCCCTGATGGGGAGGCCATCGTCACTGGTGCTGGAGACGAGACCCTGAGGT

Target sequence

GGGGCCCAGCCACCCGACACCTTGCTCCCCTCTCCTTCAGTCCCCCAGCACTGTCCCGAGGCAC

Reference

Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.