Basic Information
VIS ID
TVIS30015639
Fusion event
HIV-VAV1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
6847293/6847282 (Hg38)
End
6847219/6847282 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
VAV1
miRNAs that regulate target gene
hsa-mir-26b-5p
Nearest miRNA
hsa-mir-1227/Upstream/110504; hsa-let-7e/Downstream/770157;
Nearest TSS
ENST00000633603/Upstream/11473; ENST00000596944/Downstream/40284;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/79133, chr19-CpG: 25/Downstream/227459
Nearest cancer related gene
VAV1(OG, No orient, 0)
Upstream sequence
attacaggcgtgagccacagcgcccagccagtgccatttggtatatttgcaatactgcgccgccatcactgccgtttagctccaaaacattctcagcacc
Downstream sequence
cccaagagaaaccccatcccgggcagttgctcctgcctcccgcagcccccgggaaccaagggtctccttcctgtctctgtggattggcgtgttctgggca
Target sequence
gccagtgccatttggtatatttgcaatactgcgccgccatcactgccgtttagctccaaaacattctcagcacc
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
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