Basic Information
VIS ID
TVIS30015645
Fusion event
HIV-MARCH2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
8486960/8422076 (Hg38)
End
8487063/8422076 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
MARCH2
miRNAs that regulate target gene
hsa-mir-148b-3p ; hsa-mir-377-3p ; hsa-mir-6837-3p ; hsa-mir-6754-3p ; hsa-mir-412-3p ; hsa-mir-345-3p ; hsa-mir-141-5p ; hsa-mir-6768-5p ; hsa-mir-6732-3p ; hsa-mir-548as-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac
Nearest miRNA
hsa-mir-1227/Upstream/32696; hsa-let-7e/Downstream/1616278;
Nearest TSS
ENST00000633603/Upstream/149; ENST00000597813/Downstream/5751;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/8464, chr19-CpG: 18/Downstream/8594
Upstream sequence
GGCTCCTCTCCACCGTCATCCGTGCCTTGGACACACCGAGGTGAGTGGTGACTGCGTGGATATCCTGGCCTTTGTTGCCTCTTCTCTCTGGGCGCAGTGA
Downstream sequence
tagctttggccgggtctgattctttaggaaaagctgaaattccagattattatgtgaaatctgaaggtcaaatgttgtcaagtaaCACACTTTTGGGAGG
Target sequence
GTTTCTCCCAGCCTGGGGTTAGAAGTCCAACCGTTGACAGAGGGCCAAGTGGGTAAATAGAGAAAGAGACAcaaacagttatcgccttgtggaaacagaggcc
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate