Basic Information
VIS ID
TVIS30015656
Fusion event
HIV-HNRNPM integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
8527192/8462308 (Hg38)
End
8527040/8462308 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
HNRNPM
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-mir-26b-5p ; hsa-let-7f-1-3p ; hsa-mir-615-3p ; hsa-mir-18a-3p ; hsa-mir-193b-3p ; hsa-mir-484 ; hsa-mir-331-3p ; hsa-mir-191-5p ; hsa-mir-15b-5p ; hsa-mir-183-5p ; hsa-mir-93-5p ; hsa-mir-92a-3p ; hsa-mir-29a-3p
Nearest miRNA
hsa-mir-1227/Upstream/72928; hsa-let-7e/Downstream/1576046;
Nearest TSS
ENST00000633603/Upstream/339; ENST00000598367/Downstream/1189;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/16427, chr19-CpG: 60/Downstream/23347
Upstream sequence
TCACGCAGACTTCTTTCCTATAGATTTGGATTGCCTCTAGTCATGAATGAGTCTTCCAGACAGGGAAATTGATACGGAAATCTGTGGAATAGCTTGTTTG
Downstream sequence
TGGTGGGAGGAAAATCAAGGACATATTGTTAACGTGTTTTCACCTACTTTTACTGCACACCTGTAATGCCTAGTTCGGTGGTTTAGAGAATATGGAGTGT
Target sequence
CCACCAATGAGAGCGTATGTGTAAAACCTCCTCCCTTCCCCAGAAAAGTAAATCACGCAGACTTCTTTCCTATAGATTTGGATTGCCTCTAGTCATGAATGAGTCTTCCAGACAGGGAAATTGATACGGAAATCTGTGGAATAGCTTGTTTG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate