Basic Information
VIS ID
TVIS30015666
Fusion event
HIV-chr19 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
9758727/9648051 (Hg38)
End
9758873/9648051 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA19B
Nearest miRNA
hsa-mir-1227/Upstream/1258671; hsa-let-7e/Downstream/390303;
Nearest TSS
ENST00000633603/Upstream/26652; ENST00000613300/Downstream/26993;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/26733, chr19-CpG: 25/Downstream/26753
Nearby gene
ZNF562(No orient, 610)
Upstream sequence
cccaggctggtttgaactccttggctcaagggatctttttgcctcagcctccaaaagtgctgggattacaggcctgagccactattcccaaccTAGATGA
Downstream sequence
ATGAAGTATTTTTAAGtgatccattatgtcacagtcgagcttatccaggaatacaaggttgatgtaacattggaaaagcaataaatacaaataccacatt
Target sequence
CTCTTATAGATTAAGAATTTAGAAATAGTAGGAACATGCCCCACTACAGTATATGACAGTCATTATATACAAATATCATTAAGGGACAATTTTTTAAAAATCACAATGTTATTCAAACATAGCTCCATAACATATTAGTAAAGGTC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate