Basic Information
VIS ID
TVIS30015670
Fusion event
HIV-chr19 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
10317380/10206704 (Hg38)
End
10317167/10206704 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA19B
Nearest miRNA
hsa-mir-1227/Upstream/168291; hsa-let-7e/Downstream/23709;
Nearest TSS
ENST00000633603/Upstream/5507; ENST00000588963/Downstream/24568;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/11516, chr19-CpG: 62/Downstream/17238
Nearby gene
DNMT1(No orient, 11625)
Nearest cancer related gene
DNMT1(TSG, No orient, 11625)
Upstream sequence
GTCCCATAGCGTGTGCTGGGTAGAGCCGCCTACTCCTCGTGGGGCCTTTGAGCAGGCAGACAGCTCTCTGTTGGGGATCACAAGAGGCTTGCTGCcaagc
Downstream sequence
cctgtgggtttttccttcaaagagcccttgagtcagctgatctgcccctcctgggcccctggcccaggtcaccctcacctttctgctggatgcctgccca
Target sequence
CAGCACTCAGTAACAATGGGGACACTTTACCACCCTTACCCTGGAAGGGCCTCAGAAGCACTCTCTCCAGGCTCGACTTGCCTAAGCTAGGAATCAGATCTGCAGAAACCCAAGTCCCATAGCGTGTGCTGGGTAGAGCCGCCTACTCCTCGTGGGGCCTTTGAGCAGGCAGACAGCTCTCTGTTGGGGATCACAAGAGGCTTGCTGCcaagc
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate