Basic Information
VIS ID
TVIS30015677
Fusion event
HIV-chr19 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
10317375/10206699 (Hg38)
End
10317571/10206699 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA19B
Nearest miRNA
hsa-mir-1227/Upstream/168286; hsa-let-7e/Downstream/23714;
Nearest TSS
ENST00000633603/Upstream/5502; ENST00000588963/Downstream/24573;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/11511, chr19-CpG: 62/Downstream/17243
Nearby gene
DNMT1(No orient, 11620)
Nearest cancer related gene
DNMT1(TSG, No orient, 11620)
Upstream sequence
CCCAAGTCCCATAGCGTGTGCTGGGTAGAGCCGCCTACTCCTCGTGGGGCCTTTGAGCAGGCAGACAGCTCTCTGTTGGGGATCACAAGAGGCTTGCTGC
Downstream sequence
ccctacctcaccgaatcccctgaatggcttctcagggctcttagggtaaacccaaccctaccttctccgctgcagcccacaaggcctcagtgcccagccc
Target sequence
caagccctgtgggtttttccttcaaagagcccttgagtcagctgatctgcccctcctgggcccctggcccaggtcaccctcacctttctgctggatgcctgcccagcctcattcctgggctgctacttggccccctcaccatccattcaccacggaagaagttcatcagaacccaaatctgatcatgttagctcct
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
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